Université de Bordeaux
LabEx TRAILCluster of Excellence
Cluster of excellence


Any publication issued from the TRAIL community must have the following sentence in the acknowledgments or in the financial support:

"This study was achieved within the context of the Laboratory of Excellence TRAIL ANR-10-LABX-57."


Latest TRAIL publications (2019):

WP 1- MRI-Guided HIFU

MRGHIFU project:

  • Valéry Ozenne, Pierre Bour, Baudouin Denis de Senneville, SolennToupin, Alexis Vaussy, Matthieu Lepetit‐Coiffé, Pierre Jaïs, Hubert Cochet, Bruno Quesson, Assessment of left ventricle magnetic resonance temperature stability in patients in the presence of arrhythmias, NMR in Biomedicine, July 2019 Read here
  • Valéry Ozenne, Charlotte Constans, Pierre Bour, Mathieu D. Santin, Romain Valabregue, Harry Ahnine, Pierre Pouget, Stéphane Lehericy, Jean-François Aubry, Bruno Quesson, MRI monitoring of temperature and displacement for transcranial focus ultrasound applications, Neuroimage, Nov 2019 Read here

WP2 - New sequences

HRDTI project:

  • Marion Griton, Ibtihel Dhaya, Renaud Nicolas, Gérard Raffarde, Olivier Periota, Bassem Hiba, Jan Pieter Konsmana, Experimental sepsis-associated encephalopathy is accompanied by altered cerebral blood perfusion and water diffusion and related to changes in cyclooxygenase-2 expression and glial cell morphology but not to bloodbrain barrier breakdown, Brain, Behavior, and Immunity, Nov 2019 Read here


  • Faller, T.L., Trotier, A.J., Miraux, S. et al., Radial MP2RAGE sequence for rapid 3D T1 mapping of mouse abdomen: application to hepatic metastases, Eur Radiol (2019). Read here


ONCOFLUX project:

  • Crémillieux Y, Dumont U, Mazuel L, Salvati R, Zhendre V, Rizzitelli S, Blanc J, Roumes H, Pinaud N and Bouzier-Sore A-K (2019) Online Quantification of Lactate Concentration in Microdialysate During Cerebral Activation Using 1H-MRS and Sensitive NMR Microcoil. Front. Cell. Neurosci. 13:89. Read here
  • Yannick Crémillieux, Yoann Montigaud, Clémence Bal, Noël Pinaud, Vi Pham, Sophie Perine, Marco Natuzzi, François Lux, Olivier Tillement, Nobuyasu Ichinose, Bei Zhang, Jérémie Pourchez, Three‐dimensional quantitative MRI of aerosolized gadolinium‐based nanoparticles and contrast agents in isolated ventilated porcine lungs, Magnetic Resonance in Medicine, oct 2019 Read here

TRAIL DNP project:

  • Gérard Audran, Lionel Bosco, Paul Brémond, Natacha Jugniot, Sylvain R. A. Marque, Philippe Massot, Philippe Mellet, Tataye Moussounda Moussounda Koumba, Elodie Parzy, Angélique Rivot, Eric Thiaudière, Pierre Voisin, Carina Wedla and Toshihide Yamasakia, Enzymatic triggering of C–ON bond homolysis of alkoxyamines, Organic chemistry Frontiers, sept 2019 Read here

WP4 - Tracers and contrast agents

FITTING project:

  • Zoeisha S. Chinoy, Clément Bodineau, Camille Favre, Kelley W. Moremen, Raúl V. Durán and Frédéric Friscourt, Selective Engineering of Linkage-Specific α2,6-N-Linked Sialoproteins Using Sydnone-Modified Sialic Acid Bioorthogonal Reporters, Angewandte Chemie International Edition, 2019, 58, 4281-4285. Read here


  • Isabelle Sasaki, Jonathan Daniel, Sébastien Marais, Jean-Baptiste Verlhac, Michel Vaultier and Mireille Blanchard-Desce, Soft fluorescent organic nanodots as nanocarriers for porphyrins, Journal of Porphyrins and Phthalocyanines, Oct 2019 Read here

PRITOR project:

  • Morgat C., Schollhammer R., Macgrogan G., Barthe N., Vélasco V., Vimont D., et al. (2019) Comparison of the binding of the gastrin-releasing peptide receptor (GRP-R) antagonist 68Ga-RM2 and 18F-FDG in breast cancer samples. PLoS ONE 14(1):e0210905. Read here
  • Clément Morgat, Adrien Chastel, Vincent Molinie, Romain Schollhammer, Gaétan Macgrogan, Valérie Vélasco, Bernard Malavaud, Philippe Fernandez and Elif Hindié, Neurotensin Receptor-1 Expression in Human Prostate Cancer: A Pilot Study on Primary Tumors and Lymph Node Metastases, International journal of molecular sciences, April 2019, 20(7), 1721 Read here
  • Romain Schollhammer, Henri De Clermont Gallerande, Mokrane Yacoub, Marie-Laure Quintyn Ranty, Nicole Barthe, Delphine Vimont, Elif Hindié, Philippe Fernandez and Clément Morgat, Comparison of the radiolabeled PSMAinhibitor 111In-PSMA-617 and the radiolabeled GRP-R antagonist 111In-RM2 in primary prostate cancer samples, EJNMMI Research, 019, 9: 52 Read here

SUPSIFLU project:

  • Morgan Cormier, Eric Fouquet and Philippe Hermange, Expedient synthesis of a symmetric cycloheptyne-Co2(CO)6 complex for orthogonal Huisgen cycloadditions,  Organic Chemistry Frontier, April 2019, 2019,6, 1114-1117 Read here

TARGLIN project:

  • Konate K, Dussot M, Aldrian G, Vaissière A, Viguier V, Ferreiro Neira I, Couillaud F, Vivès E, Boisguerin P & Deshayes S (2018). Peptide-based nanoparticles to rapidly and efficiently “Wrap’n Roll” siRNA into cells. Bioconjug Chem Read here

WP5 - Biological bioimaging markers

BRAIN-RESV project:

  • Ursule Dumont, Stéphane Sanchez, Benjamin Olivier, Jean-François Chateil, Luc Pellerin, Marie-Christine Beauvieux, Anne-Karine Bouzier-Sore, Hélène Roumes, Maternal consumption of piceatannol: A nutritional neuroprotective strategy against hypoxia-ischemia in rat neonates, Brain research, 2019 Aug 15;1717:86-94 Read here

GMCOG project:

  • Jason H. Su, Francis T. Thomas, Willard S. Kasoff, Thomas Tourdias, Eun Young Choi, Brian K. Rutt and Manojkumar Saranathan, Thalamus Optimized Multi Atlas Segmentation (THOMAS): fast, fully automated segmentation of thalamic nuclei from structural MRI. NeuroImage, 2019, 194, 272-282. Read here
  • Koubiyr, I., Deloire, M., Besson, P., Coupé, P., Dulau, C., Pelletier, J., Tourdias T., Audoin B., Brochet B., Ranjeva J.-P., and Ruet, A. (2018). Longitudinal study of functional brain network reorganization in clinically isolated syndrome, Multiple Sclerosis Journal Read here
  • Planche V, Su J, Mournet S, Saranathan M, Dousset V, Han M, Rutt B and Tourdias T, White-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis. Multiple Sclerosis Journal, 2019 Read here
  • Ismail Koubiyr, Pierre Besson, Mathilde Deloire, Julie Charre-Morin, Aurore Saubusse, Thomas Tourdias, Bruno Brochet and Aurélie Ruet, Dynamic modular-level alterations of structural-functional coupling in clinically isolated syndrome, Brain, sept 2019 Read here

INNES project:

  • Stephen F.Carter, Karl Herholz, Pedro Rosa-Neto, Luc Pellerin, Agneta Nordberg, Eduardo R.Zimmer, Astrocyte Biomarkers in Alzheimer’s Disease, Trends in Molecular Medicine (2019) 1397 1-19 Read here
  • Sarah Geller, Yoan Arribat, Citlalli Netzahualcoyotzi, Sylviane Lagarrigue, Lionel Carneiro, Lianjun Zhang, Francesca Amati, Isabel C. Lopez-Mejia, and Luc Pellerin,Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion, Cell Metabolism, Sept 2019 Read here

  • Bessem Mornagui, Raja Rezg, Cendrine Repond, Luc Pellerin, Effects of bisphenol S, a major substitute of bisphenol A, on neurobehavioral responses and cerebral monocarboxylate transporters expression in mice, Food and chemical toxicology, sept 2019 Read here


  • Kirubanandhan Lokeshwaran, Audrey Hemadou, N.S. Jayaprakash, R.R. Prasanna, Marie-Josée Jacobin-Valat, Wilfrid Dieryck, Gilles Joucla, M.A. Vijayalakshmi, Gisèle Clofent-Sanchez, Xavier Santarelli, Krishnan Venkataraman, Development of anti-chloro 192 tyrosine HDL apoA-I antibodies for the immunodiagnosis of cardiovascular diseases,  Journal of Immunological Methods, oct 2019 Read here

STEAMRI project:

  • Ilyes Benlala, MD, Patrick Berger, MD, PhD, Pierre-Olivier Girodet, MD, PhD, Claire Dromer, MD, Julie Macey, MD, François Laurent, MD, Gaël Dournes, MD, PhD, Automated Volumetric Quantification of Emphysema Severity by Using Ultrashort Echo Time MRI: Validation in Participants with Chronic Obstructive Pulmonary Disease, Radiology, 2019 Jun 4:190052 Read here
  • Ilyes Benlala, MD, François Hocke, MD, Julie Macey, MD, Stéphanie Bui, MD, Patrick Berger, MD, PhD, François Laurent, MD, Gaël Dournes, MD, PhD, Quantification of MRI T2-weighted High Signal Volume in Cystic Fibrosis: A Pilot Study, Radiology, nov 2019 Read here

TBI project:

  • Tifenn Clément, Jeong B. Lee, Aleksandra Ichkova, Beatriz Rodriguez-Grande,  Marie-Line Fournier,  Justine Aussudre, Michael Ogier, Elizabeth Haddad, Frederic Canini, Muriel Koehl, Djoher Nora Abrous, Andre Obenaus, Jerome Badaut,Juvenile mild traumatic brain injury elicits distinct spatiotemporal astrocyte responses, Glia, oct 2019 Read here
  • Jerome Badaut, Arash Adami, Lei Huang, André Obenaus, Noninvasive magnetic resonance imaging stratifies injury severity in a rodent model of male juvenile traumatic brain injury, J Neuro Res, March 2019 Read here
  • Aleksandra Ichkova, Andrew M. Fukuda, Nina Nishiyama, Germaine Paris, Andre Obenaus and Jerome Badaut, Small Interference RNA Targeting Connexin-43 Improves Motor Function and Limits Astrogliosis After Juvenile Traumatic Brain Injury, ASN Neuro, Nov 2019 Read here
  • J Badaut, J Zang, 17th international conference on Brain Edema and Cellular Injury, J Neuro Res, Nov 2019, Read here
  • Virginie Dinet, Klaus G. Petry and Jerome Badaut, Brain–Immune Interactions and Neuroinflammation After Traumatic Brain Injury, Frontiers in Neurosciences, Nov 2019 Read here

WP6 - Mathematical simulation and modeling

ARM project:

  • B Denis de Senneville, R Cardiet, J Trotier, E Ribot,L Lafitte, L Facq, S Miraux, Optimizing 4D abdominal MRI: Image denoising using an iterative back-projection approach, Physics in Medicine and Biology, nov 2019 Read here
  • Baudouin Denis de Senneville, Nora Frulio, Hervé Laumonier, Cécile Salut, Luc Lafitte, Hervé Trillaud, Liver contrast-enhanced sonography: Computer-assisted differentiation between focal nodular hyperplasia and inflammatory hepatocellular adenoma by reference to microbubble transport patterns, European Radiology, nov 2019 Read here
  • L Lafitte, C Zachiu, L G W Kerkmeijer, M Ries and B Denis de Senneville, Accelerating multi-modal image registration using  a supervoxel-based variational framework, Physics in Medicine and Biology, Nov 2018 Read here


  • Pierrick Coupé, José Vicente Manjón, Enrique Lanuza & Gwenaelle Catheline, Lifespan Changes of the Human Brain In Alzheimer’s Disease, Nature Scientific Report, May 2019, 9:3998 Read here
  • Kilian Hett, Vinh-Thong Ta, Gwenaëlle Catheline, Thomas Tourdias, José V. Manjón, Pierrick Coupé, Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification, Alzheimer’s Disease Neuroimaging Initiative, oct 2019 Nature Scientific Reports Read here

  • Pierrick Coupé, Boris Mansencal, Michaël Clément, Rémi Giraud, Baudouin Denis de Senneville, Vinh-Thong Ta, Vincent Lepetit and José V. Manjon, AssemblyNet: A Novel Deep Decision-Making Process for Whole Brain MRI Segmentation, MICCAI, oct 2019 Read here


  • Benjamin Taton, Renaud De La Faille, Julien Asselineau, Paul Perez,Pierre Merville, Thierry Colin, Christian Combe, Steven Sourbron, Nicolas Grenier, A prospective comparison of dynamic contrast-enhanced MRI and 51CrEDTA clearance for glomerular filtration rate measurement in 42 kidney transplant recipients European Journal of Radiology, Nov  2019 Read here


  • Pierre Antoine Linck, Gregory Kuchcinski, Fanny Munsch, Romain Griffier, Renaud Lopes, Gosuke Okubo, Sharmila Sagnier, Pauline Renou, Julien Asselineau, Paul Perez, Vincent Dousset, Igor Sibon, Thomas Tourdias, Neurodegeneration of the Substantia Nigra after Ipsilateral Infarct: MRI R2* Mapping and Relationship to Clinical Outcome, Radiology 2019; 291:438–448. Read here
  • Aurélien Olivier, Olivier Moal, Bertrand Moal, Fanny Munsch, Gosuke Okubo, Igor Sibon, Vincent Dousset, Thomas Tourdias, Active learning strategy and hybrid training for infarct segmentation on diffusion MRI with a U-shaped network, Journal of Medical Imaging, oct 2019 Read here

  • Sharmila Sagnier,  Gosuke Okubo, Gwenaëlle Catheline, Fanny Munsch, Antoine Bigourdan, Sabrina Debruxelles, Mathilde Poli, Stéphane Olindo, Pauline Renou, François Rouanet, Vincent Dousset, Thomas Tourdias, Igor Sibon, Chronic Cortical Cerebral Microinfarcts Slow Down Cognitive Recovery After Acute Ischemic Stroke, Stroke, May 2019 Read here

  • Sharmila Sagnier, Fanny Munsch, Antoine Bigourdan, Sabrina Debruxelles, Mathilde Poli, Pauline Renou, Stephane Olindo, Francois Rouanet, Vincent Dousset, Thomas Tourdias, and Igor Sibon, The Influence of Stroke Location on Cognitive and Mood Impairment. A Voxel-Based Lesion-Symptom Mapping Study, Journal of Stroke and Cerebrovascular Diseases, May 2019 Read here

MOD project:

  • Crombé A, Périer C, Kind M, De Senneville BD, Le Loarer F, Italiano A, Buy X, Saut O, T2-based MRI Delta-radiomics improve response prediction in soft-tissue sarcomas treated by neoadjuvant chemotherapy, Journal of Magnetic Resonance Imaging (2018) Read here

WP7 - Cohort imaging methodology

ACTE project:

  • G. Di Scala, M. Dupuy, E. Guillaud, E. Doat, E. Barse, B. Dillhareguy, F.A.M. Jean, M. Audiffren, J.R. Cazalets & S. Chanraud (2019): Efficiency of Sensorimotor Networks: Posture and Gait in Young and Older Adults, Experimental Aging Research Read here
  • Edde Manon, Di Scala Georges, Dupuy Maud, Dilharreguy Bixente, Catheline Gwenaelle, Chanraud Sandra, Learning-driven cerebellar intrinsic functional connectivity changes in men, Journal of Neuroscience Research, nov 2019, Read here

COBRASCAN project:

  • Coste F, Benlala I, Dournes G, Dromer C, Blanchard E, Girodet P-O, Montaudon M, Baldacci F, Picard F, Marthan R, Laurent F, Berger P, Quantitative CT assessment of bronchial and vascular alterations in severe precapillary pulmonary hypertension, International Journal COPD, 2019